Endocrine Abstracts

Selenium is an essential element for humans. Important dietary sources of selenium include meat, seafood, and grains. Selenium is incorporated into a range of selenoenzymes with antioxidant properties. Being crucial for the activity of the deiodinase enzymes, selenium is especially important for the synthesis and metabolism of thyroid hormones. Selenium in relation to thyroid diseases has been widely explored. Epidemiological studies have shown that a low selenium status is as...

Background: Little is known about the long-term outcome of the thyroid function in Graves’ disease in a large epidemiological setting.Objective: The aim was to evaluate the long-term outcome of the thyroid function in patients diagnosed with Graves’ disease in Denmark in the period 1995-2018. Our research objectives were to investigate the incidence of disease, use of antithyroid drugs, radioactive iodine, thyroidectomy and levothyroxine during...

BackgroundArtificial intelligence algorithms can be used in classification of thyroid nodules to reduce subjectivity. External validation on images collected from different ultrasound machines and other institutions are vital before wider use of these algorithms. We retrospectively analyzed the performance of AIBx on thyroid nodules with surgically proven pathology.Materials and methodsPatients harboring thyr...

Objective: Globally, cancer is one of the leading causes of death. Therefore, identification of risk factors is of paramount interest. Whether thyroid dysfunction is a cancer risk factor is currently being debated. The aim of this study was to evaluate the risk of cancer in patients diagnosed with hypothyroidism.Methods: This is a register-based nationwide cohort study of individuals diagnosed with hypothyroidism referred to Danish hospitals (followed fr...

Objective: Thyroid diseases have been shown to affect quality of life. A thyroid-specific patient-reported outcome (PRO) measuring quality of life, the ThyPRO, has recently been developed and validated using classical clinic- and psycho-metric methods. The purpose of the present study was to apply modern psychometrics to validate the measure as the extent of differential item functioning (DIF) according to sex, age, education and diagnosis, within the ThyPRO.<p class="abst...

Objective: During the development of a thyroid-specific quality of life (QoL) questionnaire, patients and clinicians rated the relative relevance of a list of possibly relevant QoL issues. In this study we compare the patient and clinician ratings.Methods: Fifteen thyroid experts and 80 thyroid outpatients (14 with non-toxic goitre, 12 nodular toxic goitre, 21 Graves’ disease, 17 thyroid associated ophthalmopathy (TAO) and 16 primary hypothyroidism)...

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abste...

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abst...

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...

PurposeThe standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients.MethodAn e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all me...